See how the actress's hair and makeup has evolved through the years.
1982
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The third generation Hollywood star played Gertie in the sci-fi hit E.T.
1984
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She played evil in Firestarter, but the 9-year-old looked angelic with her blond locks and sweet smile.
1988
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13-year-old Barrymore sported an '80s perm and brushed up brows.
1990
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The Hollywood scenester dyed her hair a buttery blond and added a swipe of matte red lipstick.
1992
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The once-troubled teen made her comeback with Poison Ivy and auburn hair. "I find redheads so beautiful," Barrymore has said. "To play in their field is so much fun."
1995
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For the Los Angeles premiere of Batman Forever, Barrymore wore a daisy in her stylishly tousled pixie.
1996
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Ever-experimental, the 21-year-old Scream star dyed her hair blue-black and lightened her complexion with pale powder.
1997
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Drew brought the cute with an edgy version of a Louise Brooks bob.
1998
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The Wedding Singer leading lady presented at the Oscars with her signature fresh daisies in her then platinum hair.
2000
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At the Academy Awards, the Charlie's Angels doyenne got romantic with sheer rose lips, petal pink cheeks, and a wash of olive eye shadow.
2003
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Drew went all out at the London premiere of Charlie's Angels: Full Throttle with a major dusting of Kabuki-style powder.
2003
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"Black liner and lashes really make her sparkly eyes come alive," her makeup artist Gucci Westman has said. Sexy beach waves completed the look.
2004
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Barrymore swapped her daisies for a gardenia at the 50 First Dates premiere. Said hairstylist Lona Vigi, "She loves hair accessories that are playful and fun, just like her personality."
2005
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Red lips and red hair for the Fever Pitch beauty.
2007
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For a Versace event, Barrymore let her couture take center stage. "The dress had a busy neckline, so we kept her hair straight and simple," Vigi has said. A strip of false lashes gave her sexy bedroom eyes.
2007
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The Music and Lyrics lead - and new face of Cover Girl - named her beauty must-haves as, "concealer, blush and a chocolaty, smoky, smudgy eyeliner."
2009
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Barrymore channeled Monroe for the Globes. "She'd been dark for a while, so we brightened her look with this platinum hue," said colorist Tracey Cunningham.
2009
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The Grey Gardens star drew inspiration for her premiere hair from her eccentric character's '40s heyday: "I wore a headdress to honor Edie." The gorgeous champagne veil was accented with a beaded flower.
2009
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"This is the craziest look I've ever given her!" colorist Tracey Cunningham said of Drew's Whip It premiere look. "I used clear foils and a stencil that I made out of paper to get everything to line up."
2009
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For Drew's October InStyle cover, hairstylist Mark Townsend used pomade to add texture to the look. "We didn't want the hair to look to done," he said. "We wanted the hair to have a little edge to it."
2010
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Better than ever! The Going the Distance lead turned heads with a long ombre mane with lots of volume and cool pink blush courtesy of her longtime makeup artist, Debra Ferullo.
2011
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Barrymore switched up her look with auburn locks. "It's a warm red," said colorist Tracey Cunningham. "It looks really natural on her skin tone. She's totally committed to it - we've been talking about it for a couple of months at least."
2012
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The newly-engaged star pinned back her ombre locks for the premiere of The Big Miracle.
2012
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Barrymore showed off her favorite hue at the Marni for H&M launch: "I heard somebody talking smack about ombre hair, and I was like, 'Oh don't you go talking s- about that, girlfriend.' I just love it!"
2012
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Back to blond at a New York City Ballet gala! "I love Drew's lighter look, and so does she," her colorist Cunningham told fashion.appleentcentre.com. "I used Redken Chromatics to achieve the beautiful blond color. Her hair looks and feels amazing, and complements her skin beautifully."
2012
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The new mom showed off auburn locks an an L.A. event for Bulgari.
2013
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Drew Barrymore lightened up for 2013 LACMA Art & Film Gala. The star arrived brighter and blonder with honey-hued tresses and a soft pink lip.
2014
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For the launch party of her photography book, Find it in Everything, a pregnant Barrymore wowed with green eyeshadow and straight, loose hair.
2015
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Barrymore, best known for her roles in E.T., Charlie's Angels, and a slew of other films, has also conquered the makeup realm with her Flower Beauty cosmetics line. "My first favorite beauty moment was when I was a kid watching women get ready in a makeup room—it was like this secret society where they all had eyelash curlers and rollers in their hair," she says.
2016
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Barrymore got experimental with her makeup at BeautyCon in N.Y.C., complementing her hazel eyes with a bold steel blue liner and a matte peach lip.
2017
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The Santa Clarita Diet star rocked natural beachy waves and a glossy lip to a special screening of the Netflix original series.